The stimulating effects of pot will override the sedating effects of the Xanax. You could use this medication more efficiently if you very slowly lowered your dose... or, identify times when the dose is not needed and skip those doses lowering your tolerance. Of course, if the dosing of the medication is right for you - people with panic disorder routinely take doses like this - perhaps, you should not smoke pot for a few hours before bed. That's not compatable to many people's lives. It's a dilemma.