Quote:
Originally Posted by Pharm Girl
You found the diagrams I was looking for!
The first one is the Nabilone/Cesamet.
Good man..........~
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yes they are quite different, yet they are both still cannabinoids...look at endogenous cannabinoids, they look even more different...how can this be?...well armed with our modern day v2.0 definition, you dont need to look like anything anymore to be a cannabinoid...you just need to bind to one of the cannabinoid receptors...the first one, cesamet (aka nabilone) came from the SAR (structure activity relationship) research of the classical cannabinoids/synthetic cannibinoids based on thc...the second one win 55,212-2 was born out the the SAR of pravadoline....since some of these compounds are inherently flexible (look at endogenous cannabinoids), it makes for fun computational work (although a little to nerdy for these forums)